Our lab is interested in understanding Extracellular Matrix / Cell / Mechanobiology in 3D contexts. For this, we first aim to tissue-engineer biomimetic and regenerative 3D nanofiber scaffolds by using innate extracellular matrix proteins (e.g., fibronectin) as a building block and by applying various addictive manufacturing platforms.
We will then deep dive into investigating integrin-mediated signalling pathways to systemically understand how different cells sense and respond to the engineered extracellular matrices across various biological and temporal scales. Our focus is primarily on skin cells and tissues, but also on any other cell types including stem cells, epithelial cells, cardiomyocytes, and neurons.
Altogether, our lab aspires to better understand physiologically-relevant mechanobiology and to ultimately design “regenerative niches” for functional implants (e.g., wound dressing) and in vitro model systems.
[17] Siontas O and Ahn S*, “Challenges in AAV-based Retinal Gene Therapies and the Role of Magnetic Nanoparticle Platforms” (2024) Journal of Clinical Medicine
[16] Ahn S*, “Tissue-engineered fibrillar fibronectin matrices are not only lovely, but also functional for regenerative medicines and in vitro model systems” (2024) Biomaterials and Biosystems
[15] Ahn S, Siontas O, Koester J, Krol J, Fauser S, Müller DJ, “Magnetically guided adeno-associated virus delivery for spatially targeted transfection in porcine retina and eye” (2024) Advanced Healthcare Materials
[14] Ahn S*, Jain A, Kasuba KC, Treutlein B, Müller DJ*, “Customizable multi-component fibrillar extracellular matrices to modulate tissue-specific cellular dynamics” (2024) Biomaterials, *corresponding authors
[13] Ahn S*, Sharma U, Kasuba KC, Strohmeyer N*, Müller DJ*, “Engineered biomimetic fibrillar fibronectin matrices regulate cell adhesion initiation, migration, and proliferation via α5β1 integrin and syndecan-4 crosstalk” (2023) Advanced Science, *corresponding authors
[12] Ahn S, Chantre CO, Ardoña HAM, Gonzalez GM, Campbell PH, Parker KK, “Biomimetic and Estrogenic Fibers Promote Tissue Repair in Mice and Human Skin via Estrogen Receptor β” (2020) Biomaterials
[11] Ahn S, Ardoña HAM, Campbell PH, Gonzalez GM, Parker KK, “Alfalfa Nanofibers for Dermal Wound Healing” (2019) ACS Applied Materials & Interfaces Selected as supplementary cover article
[10] Chantre CO, Gonzalez GM, Ahn S, Cera L, Campbell PH, Hoerstrup SP, Parker KK. “Porous Biomimetic Hyaluronic Acid and Extracellular Matrix Protein Nanofiber Scaffolds for Accelerated Cutaneous Tissue Repair” (2019) ACS Applied Materials & Interfaces
[9] MacQueen LA, Alver CG, Chantre CO, Ahn S, Cera L, Gonzalez GM, O’Connor BB, Drennan DJ, Peters MM, Motta SE, Zimmerman JF. “Muscle Tissue Engineering in Fibrous Gelatin: Implications for Meat Analogs” (2019) NPJ Science of Food
[8] Eweje F, Ardoña HA, Zimmerman JF, O'Connor BB, Ahn S, Grevesse T, Rivera KN, Bitounis D, Demokritou P, Parker KK. “Quantifying the Effects of Engineered Nanomaterials on Endothelial Cell Architecture and Vascular Barrier Integrity using a Cell Pair Model” (2019) Nanoscale
[7] Ahn S, Ardoña HAM, Lind JU, Eweje F, Kim SL, Gonzalez GM, ... & Parker KK, “Mussel-inspired 3D Fiber Scaffolds for Heart-on-a-chip Toxicity Studies of Engineered Nanomaterials” (2018) Analytical and Bioanalytical Chemistry Selected as front cover article
[6] Chantre CO, Campbell HP, Golecki HM, Buganza AT, Capulli AK, Deravi LF, Dauth S, Sheehy SP, Paten JA, Gledhill K, Doucet YS, Abaci HE, Ahn S, Pope BD, Ruberti JW, Hoerstrup SP, Christiano AM, Parker KK, “Production-scale Fibronectin Nanofibers Promote Wound Closure and Tissue Repair in a Dermal Mouse Model” (2018) Biomaterials
[5] Ahn S, Lee KY, Parker KK, Shin K, “Formation of Multi-Component Extracellular Matrix Protein Fibers” (2018) Scientific Reports Selected as Top 100 in Cell and Molecular Biology article
[4] Ahn S, Chantre CO, Gannon AR, Lind JU, Campbell PH, Grevesse T, O’Connor BB, Parker KK. “Soy Protein/Cellulose Nanofiber Scaffolds Mimicking Skin Extracellular Matrix for Enhanced Wound Healing” (2018) Advanced Healthcare Materials Featured in NPR
[3] Capulli AK, Emmert MY, Pasqualini FS, Kehl D, Caliskan E, Lind JU, Sheehy SP, Park SJ, Ahn S, Weber B, Goss JA, Hoerstrup SP, Parker KK. “JetValve: Rapid Manufacturing of Biohybrid Scaffolds for Biomimetic Heart Valve Replacement” (2017) Biomaterials
[2] Park SJ, Gazzola M, Park KS, Park S, DiSanto V, Blevins EL, Lind JU, Campbell PH, Dauth S, Capulli AK, Pasqualini FS, Ahn S, Cho A, Yuan H, Maoz BM, Vijaykumar R, Choi JW, Deisseroth K, Lauder GV, Mahadevan L, Parker KK. “Phototactic Guidance of a Tissue-engineered Soft-robotic Ray” (2016) Science
[1] Ahn S, Deravi LF, Park SJ, Dabiri BE, Kim JS, Parker KK, Shin K, “Self-organizing Large-scale Extracellular-matrix Protein Networks” (2015) Advanced Materials Selected as front cover article
[1] (Invited oral presentation) Ahn S*, Elucidate spatiotemporal integrin-mediated mechanotransduction of engineered biomimetic fibrillar extracellular matrices, (2025) 10th International Conference on Composite Materials and Material Engineering Seoul, Korea
Nano- and micro-scale explorations in Material Science have led to novel insights into material properties unknown in human scale. By magnifying the scale of rather mundane modeling materials, we are able to inform structural formations at new scales and explore their materiality in greater depth. Utilizing a Scanning Electron Microscope (SEM) to display microscopic images and structurally translating such microscopic detail into an immersive installation, we invite you to examine the complex nano- and micro-scale forms of materials commonly found in Gund Hall's trays. The Design Laboratory is open for those that want a closer look at a selection of these materials. Through immersive and exploratory means, come rediscover your relationship with these 'banal' materials.
Collaboration with Su-Yeon (Angela) Choi, Diana Jih, Nathalie Mitchell